Publications
Peer Reviewed Articles
- Zhang Y, Gregorich ZR, Wang Y, Braz CU, Zhang J, Liu Y, Liu P, Shen J, Aori N, Hacker TA, Granzier H, Guo W*. Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy. JCI Insight. 2023 Jul 10;8(13):e170001. doi: 10.1172/jci.insight.170001. PMID: 37219949; PMCID: PMC10371347.
- Melby JA, Brown KA, Gregorich ZR, Roberts DS, Chapman EA, Ehlers LE, Gao Z, Larson EJ, Jin Y, Lopez JR, Hartung J, Zhu Y, McIlwain SJ, Wang D, Guo W, Diffee GM, Ge Y. High sensitivity top-down proteomics captures single muscle cell heterogeneity in large proteoforms. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2222081120. doi: 10.1073/pnas.2222081120. Epub 2023 May 1. PMID: 37126723; PMCID: PMC10175728.
- Bayne EF, Rossler KJ, Gregorich ZR, Aballo TJ, Roberts DS, Chapman EA, Guo W, Ralphe JC, Kamp TJ, Ge Y. Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart. J Mol Cell Cardiol. 2023; 181:89-97.
- Zhang Y, Wang C, Sun M, Jin Y, Braz CU, Khatib H, Hacker TA, Liss M, Gotthardt M, Granzier H, Ge Y, Guo W*. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB J. 2022 May; 36(5):e22302. PubMed PMID: 35394688;
- Larson, Eli J., Gregorich, Zachery R., Zhang, Yanghai, Li, Brad H., Aballo, Timothy J., Melby, Jake A., Ge, Ying and Guo, Wei*. ablation is associated with changes in the expression of titin-interacting and metabolic proteins. Mol. Omics, 2022, 18, 627-634
- Sun, M.; Jin, Y.; Zhang, Y.; Gregorich, Z.R.; Ren, J.; Ge, Y.; Guo, W*. SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20. Genes. 2022, 13, 1526. https://doi.org/10.3390/genes13091526
- Liu Y, Ding Q, Guo W*. Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function. Front. Anim. Sci. 2021; 2: 83-89; DOI: 10.3389/fanim.2021.788930.
- Wang C, Zhang Y, Methawasin M, Braz CU, Gao-Hu J, Yang B, Strom J, Gohlke J, Hacker T, Khatib H, Granzier H, Guo W*. RBM20S639Gmutation is a high genetic risk factor for premature death through RNA-protein condensates. J Mol Cell Cardiol. 2022; 165:115-129. PMID: 35041844.
- Liu Y, Ding Q, Halderson, SJ, Arriola Apelo SI, Jones AK, Pillai SM, Hoffman ML, Reed SA, Govoni, KE, Zinn SA, Guo W*. Maternal overnutrition during gestation in sheep alters autophagy associated pathways in offspring heart. Front. Genet. 2022, 12:742704. PMID: 35173761
- Wei Guo*, Chaoqun Zhu, Zhiyong Yin, Yanghai Zhang, Chunyan Wang, Andrea Sanchez Walk, Ying-Hsi Lin, Timothy A. McKinsey, Kathleen C. Woulfe, Jun Ren, and Herbert G. Chew, Jr. The Ryanodine Receptor Stabilizer S107 Ameliorates Contractility of Adult Rbm20 Knockout Rat Cardiomyocytes. Physiol Rep. 2021, 9(17): e15011. PMID: 34523360
- Maimaiti R, Zhu CQ, Zhang YH, Ding QY, Guo W*. RBM20-mediated pre-mRNA splicing has muscle-specificity and differential hormonal responses between muscles and in muscle cell cultures. Int. J. Mol. Sci. 2021, 22(6): 2928. PMID: 33805770
- Mohammadabadi M. Bordbar F, Jensen J, Du M, Guo W. Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals. Animals, 2021, 11 (3): 835. PMID: 33809500
- Mingming Sun, Yutong Jin, Chaoqun Zhu, Yanghai Zhang, Martin Liss, MichaelGotthardt, Jun RenYing Ge, Wei Guo*. RBM20 phosphorylation on serine/arginine domain is crucial to regulate pre-mRNA splicing and protein shuttling in the heart. bioRxiv 2020.09.15.297002; doi: https://doi.org/10.1101/2020.09.15.297002
- Jay W Schneider, Saji Oommen, Muhammad Y Qureshi, Sean C Goetsch, David R Pease, Rhianna S Sundsbak, Wei Guo, Mingming Sun, Han Sun, Hidehito Kuroyanagi, et al. A ribonucleoprotein-granule pathway to heart failure in human RBM20 cardiomyopathy gene-edited pigs. Nat. Med. 2020; 26(11): 1788-1800.
- Farhad Bordbar, Just Jensen, Min Du, Abeid Adam, Wei Guo, Lingyang Xu, Huijiang Gao, Lupei Zhang, Junya Li. Identification and validation of a novel candidate gene regulating net meat weight in Simmental beef cattle based on imputed next-generation sequencing. Cell Proliferation. 2020; 53(9): e12870. PMID: 32722873
- Zhi Li, Xiao-Lin Wu, Wei Guo*, Jun He, Hao Li, Guilherme J. M. Rosa, Daniel Gianola, Richard G. Tait Jr., Jamie Parham, John Genho, Tom Schultz, Stewart Bauck. Estimation of genomic breed composition of individual animals in composite beef cattle. Animal Genetics. 2020. 51(3): 457-460.
- Hanfang Cai, Chaoqun Zhu, Zhilong Chen, Rexiati Maimaiti, Mingming Sun, Richard J. McCormick, Xianyong Lan, Hong Chen and Wei Guo*. Angiotensin II influences pre-mRNA splicing regulation by enhancing RBM20 transcription through activation of the MAPK/ELK1 signaling pathway. Int. J Mol. Sci. 2019. 20(20): E5090. PMID: 31614708.
- Meng Zhang, Bo Li, Jian Wang, Sihuan Zhang, Hui Li, Lin Ma, Wei Guo, Chuzhao Lei, Hong Chen, and Xianyong Lan. Lnc9141 a and b play a different role in bovine myoblast proliferation, apoptosis and differentiation. Mol Ther Nucleic Acids. 2019. 18: 554-566. PMID: 31675668.
- Lifang Yang, Jipeng Ma, Ying Tan, Maolong Dong, Wei Guo, Lize Xiong, Jian Yang and Jun Ren. Cardiac specific overexpression of metallothionein attenuates myocardial contractile anomalies and apoptosis in L-NAME-induced hypertension. J Cell Mol Med.; 2019, 23(7): 4640-4652. PMID: 3110435.
- Zhi Li, Jun He, Jun Jiang, Richard G. Tait Jr., Stewart Bauck, Wei Guo*, Xiao-Lin Wu. Impacts of SNP genotyping call rate and SNP genotyping error rate on imputation accuracy in Holstein cattle. Hereditas (Beijing) (Yi Chuan). 2019, 41(7): 644-652. PMID: 31307973
- Jin Y., Wang J., Zhang M., Zhang S.H., Lei C.Z., Chen H., Guo W., and Lan X.Y. Role of bta-miR-204 in the regulation of adipocyte proliferation, differentiation, and apoptosis. J. Cell. Physiol. 2019, 234(7): 11037-11046. PMID: 30697738.
- Qiurong Wang, Chaoqun Zhu., Mingming Sun., Rexiati Maimaiti., Stephen P. Ford, Peter W. Nathanielsz, Jun Ren and Wei Guo*. Maternal obesity impairs fetal cardiomyocytes contractile function in sheep. FASEB J. 2019; 33(2): 2587-2598. PMID: 30289749.
- Mingming Sun, Ying Tan, Maimaiti Rexiati, Maolong Dong, and Wei Guo*. Obesity is as a Common Soil for Premature Cardiac Aging and Heart Diseases – Role of Autophagy. BBA- Mol Basis Dis. 2019, 1865(7): 1898-1904. PMID: 31109454.
- Lin Z., Wei LM., Cai W., Zhu YL., Tucholski T., Mitchell SD., Guo W., Ford PF., Diffee GM and Ying G. Simultaneous Quantification of Protein Expression and Modifications by Top-down Targeted Proteomics: A Case of Sarcomeric Subproteome. Molecular and Cellular Proteomics. 2018.18(3): 594-605. PMID: 30591534.
- Chen Z., Maimaiti R., Zhu C., Cai H., Stern A., Mozdziak P., Ge Y., Ford SP., Nathanielsz PW., and Guo W*. Z-band and M-band titin splicing and regulation by RBM20 in striated muscles. J Cell Biochem., 2018, 119(12): 9986-9996. PMID: 30133019.
- Wei Guo*, Chaoqun Zhu, Zhiyong Yin, Qiurong Wang, Mingming Sun, Huojun Cao and Marion L. Greaser. Splicing factor Rbm20 regulates transcriptional network of titin associated and calcium handling genes in the heart. Int J Biol Sci; 2018. 14(4): 369-380. PMID: 29725258.
- Zhilong Chen, Jiangping Song, Liang Chen, Hanfang Cai, Chaoqun Zhu, Mingming Sun, Allysa Stern, Paul Mozdziak, Ying Ge, Warrie J. Means and Wei Guo*. Characterization of TTN novex splicing variants across species and the role of RBM20 in novex specific exon splicing. Genes (Basel). 2018. 9(2): 86-100. PMID: 29438341.
- Maimaiti Rexiati, Mingming Sun and Wei Guo*. Muscle-specific mis-splicing and heart disease exemplified by RBM20. Genes. 2018. 9(1): 18-31. PMID: 29304022.
- Zhu C, Guo W*. Detection and quantification of the giant protein titin by SDS-agarose gel electrophoresis. MethodsX. 2017, 4:320-327.
- Ren J, Yang L, Zhu L, Xu X, Ceylan AF, Guo W, Yang J, Zhang Y. Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. Aging cell. 2017, 16(5):976-987. PMID: 28681509.
- Guo W*, Sun M. RBM20, a potential target for treatment of cardiomyopathy via titin isoform switching. Biophys Rev. 2018, 10(1): 15-25. PMID: 28577155.
- Zhu C, Yin Z, Tan B, Guo W*. Insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTOR kinase axis in a RBM20-dependent manner. BBA- Mol Basis Dis. 2017, 1863(9): 2363-2371. PMID: 28676430.
- Zhu C, Chen Z, Guo W*. Pre-mRNA mis-splicing of sarcomeric genes in heart failure. BBA- Mol Basis Dis. 2017, 1863(8): 2056-2063. PMID: 27825848.
- Guo W*, Sanchez Walk AR. Is RBM20 a Promising Target for HFpEF Therapy? Current Trends in Biomedical Engineering & Biosciences. 2017, 3(5):555625.
- Min Chen, Chuncheng Liu, Meng Wang, Hong Wang, Kuo Zhang, Yu Zheng, Zhengquan Yu, Xiangdong Li, Wei Guo, Ning Li, Qingyong Meng. Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling. Int J Biol Sci 2017; 13(10):1341-1350.
- Shuyi Wang, Wei Guo* and Jun Ren. Stress signaling in paraquat-induced target organ toxicity. ROS. 2016. 1(2): 131-140.
- Jipeng Ma, Linhe Lu, Wei Guo, Jun Ren and Jian Yang. Emerging Role for RBM20 and its Splicing Substrates in Cardiac Function and Heart Failure. Curr Pham Des. 2016. Pp. 4744-4751. PMID: 27396593.
- Zachery R. Gregorich, Ying Peng, Jeremy Wolff, Wei Guo, Huseyin Guner, Justin Doop, Timothy A, Hacker, Ying Ge. Comprehensive assessment of chamber-specific and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry, J Mol Cell Cardiol. 2015. 87: 102-112. PMID: 26268593.
- Dale C. Guenther, Grace H. Anderson, Saswata Karmakar, Brooke A. Anderson, Bradly A. Didion, Wei Guo, John P. Verstegen, and Patrick J. Hrdlicka. Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications. Chem. Sci. 2015. 6(8): 5006-5015. PMID: 26240741.
- Chaoqun Zhu, Zhiyong Yin, Jun Ren, Richard J. McCormick, Stephen P. Ford and Wei Guo*. RBM20 is an essential factor for thyroid hormone-regulated titin isoform transition. J Mol Cell Biol. 2015. 7(1): 88-90. PMID: 25573899.
- Zhiyong Yin, Jun Ren and Wei Guo*. Sarcomeric protein isoform transitions in cardiac muscle: A journey to heart failure. BBA-Molecular Basis of Disease. 2015. 1852(1): 47-52. PMID: 25446994.
- Wei Guo, Jonathan M. Pleitner, Kurt W. Saupe and Marion L. Greaser. Pathophysiological defects and transcriptional profiling in the Rbm20-/- rat model. PLOS ONE. 2013. 8(12): e84281. PMID: 24367651.
- Li S, Guo W, Dewey CN, Greaser ML. Rbm20 regulates titin alternative splicing as a splicing repressor. Nucleic Acids Res. 2013. 41(4): 2659-2672. PMID: 23307558 (Featured Article).
- Wei Guo, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan Gotthardt M et al. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat. Med. 2012. 18: 766-773. PMID: 22466703 (Article received an Editorial in Nat. Med. (18: 660-661) and Dis. Model. Mech. (5:287).
- S.J. Li, Wei Guo, B. Schmitt, M. L. Greaser. Comprehensive Analysis of Titin Protein Isoform and Alternative Splicing in Normal and Mutant Rats. J Cell Biochem. 2012. 113(4): 1265-1273. PMID: 22105831.
- Jin Zhang, Wei Guo, Liangcai Shen, Qiuyue Liu, Xuemei Deng, Xiaoxiang Hu and Ning Li. Development of a porcine cDNA microarray: Analysis of clenbuterol responding genes in pig (Sus scrofa) internal organs. Journal of Integrative Agriculture. 2012. 11(11): 1877-1883.
- Qiuyue Liu, Jin Zhang, Wei Guo, Yiqiang Zhao, Xiaoxiang Hu and Ning Li. Identifying lipid metabolism genes in pig liver after clenbuterol administration. Frontiers in Bioscience. 2012. E4: 2605-2612. PMID: 22652664.
- Wei Guo, Sheila J. Bharmal, Karla Esbona, and Marion L. Greaser. Titin Diversity-Alternative Splicing Gone Wild. J Biomed Biotechnol. 2010. PMID: 20339475.
- Yuanhai You, Xun Zeng, Wei Guo, Yan Yin, Maojun Zhang and Jianzhong Zhang. Development of a multiplex PCR-microarray method for detection of important enteropathogen. China Biotechnology. 2009. 29(12): 79-84.
- Marion L. Greaser, Chad M. Warren, Karla Esbona,Wei Guo,Yingli Duan, Amanda M. Parrish, Paul R. Krzesinski, Holly S. Norman, Sandra Dunning, Daniel P. Fitzsimons, and Richard L. Moss. Mutation that Dramatically Alters Rat Titin Isoform Expression and Cardiomyocyte Passive Tension. J Mol Cell Cardiol. 2008. 44(6), 983-91. PMID: 18387630 (Article received an Editorial: J Mol Cell Cardiol. 44(6): 976-978.).
- W. Guo, S.H. Wang, H.J. Cao, K. Xu, J Zhang, Z. L. Du, W. Lu, J.D. Feng, Li Ning and C.H. Wu. Microarray comparison of gene expression in adipose tissue between Chinese Xiang pig and Large White pig. 2008. Asian-Aust. J. Anim. Sci. 21(1): 11-18.
- J Zhang, W. Guo, BL Fan, WJ Zhu, LB Zheng, QY Liu, XM Deng, XX Hu and N Li. Apoliprotein D up-regulated in pig adipose tissue with administration of clenbuterol. Animal Husbandry & Veterinary Medicine. 2008. 1: 3-7.
- Jin Zhang, Qiang He, Qiu Y. Liu, Wei Guo, Xue M. Deng, Wei W. Zhang, Xiao X. Hu, Ning Li. Differential gene expression profile in pig adipose tissue treated with/without clenbuterol. BMC Genomics. 2007. 8:433, PMID: 18039366.
- Q Wang, H.M. Xu, W. Guo. C8orf4 gene expression profile in Human Colorectal Cancer with different differentiation grades. 2005. Acad. J. PLA. P.G. Med. Sch. 26(6): 456-458.
- W. Guo, M.X. Chu, X.M. Deng, J.D. Feng, Ning Li and Changxin Wu; Association of a single codon deletion in bone morphogenetic protein 15 gene with prolificacy in Small Tail Han Sheep. Asian-Aust. J. Anim. Sci. 2004. 17(11): 1491-1495.
- X Zhao, N Li, W Guo, X Hu, Z Liu, G Gong, A Wang, J Feng and C Wu. Further Evidence for Paternal Inheritance of Mitochondrial DNA in the Sheep (Ovis aries); Heredity. 2004. 93(4): 399-403. PMID: 15266295.
- Mingxing Chu, Jinhua Cheng and Wei Guo. Preliminary studies of microsatellite markers OarAE101 and BM1329 in five sheep breeds. Acta Genetica Sinica (Journal Genetics and Genomics)., 2001. 28(6): 510~517. PMID: 11431983.
Book Chapter
- Guo W. and Greaser, M.L. 2022. “Muscle Structure, Proteins and Meat Quality” in “New aspects of meat quality-from genes to ethics”, 2ed. Peter Purslow, Elsevier, Philadelphia, PA, PP15-37.
- Greaser, M.L. and Guo W. 2011. “Post-mortem Muscle Chemistry” In: “Handbook of Meat and Meat Processing, Second Edition”. YH Hui, CRC Press, Boca Raton, FL, pp70-78.
- Greaser, M.L. and Guo W. 2014. “Proteins” In “Handbook of Muscle Foods Analysis, Second Edition”, Leo M.L.Nollet, Fidel Toldra, CRC Press, Boca Raton, FL, PP357-368
- Guo W. and Greaser, M.L. 2016. “Muscle Structure, Proteins and Meat Quality” in “New aspects of meat quality-from genes to ethics”, first edition. Peter Purslow, Elsevier, Philadelphia, PA, PP13-32
Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47092037/?sort=date&direction=ascending